GAVRETO, also known as pralsetinib, is not chemotherapy or an immunotherapy. GAVRETO is taken by mouth once daily. It is used to treat cancer caused by abnormal RET genes in adults with non–small cell lung cancer that has spread (also known as metastatic) whether or not they received treatment in the past.
It is not known if GAVRETO is safe and effective in children. GAVRETO was approved based on the percentage of patients whose tumor size shrank or disappeared after treatment and how long that response lasted. There are ongoing studies to confirm the benefit of GAVRETO.
It is important to remember to take GAVRETO on an empty stomach. Do not eat for at least 2 hours before and at least 1 hour after taking GAVRETO.
Your doctor will do a biomarker test to decide if GAVRETO is right for you.
RET=rearranged during transfection.
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GAVRETO is a prescription medicine used to treat certain cancers caused by abnormal rearranged during transfection (RET) genes in:
Your healthcare provider will perform a test to make sure that GAVRETO is right for you.
It is not known if GAVRETO is safe and effective in children younger than 12 years of age.
GAVRETO was approved based on the percentage of patients whose tumor size shrank or disappeared after treatment and how long that response lasted. There are ongoing studies to confirm the benefit of GAVRETO.
GAVRETO may cause serious side effects, including
Lung Problems: GAVRETO may cause severe or life-threatening inflammation of the lungs during treatment, that can lead to death. Tell your healthcare provider right away if you have any new or worsening symptoms, including shortness of breath, cough, or fever.
High blood pressure (hypertension): High blood pressure is common with GAVRETO and may sometimes be severe. You should check your blood pressure regularly during treatment with GAVRETO. Tell your healthcare provider if you have increased blood pressure readings or get any symptoms of high blood pressure, including confusion, dizziness, headaches, chest pain or shortness of breath.
Liver problems: Liver problems (increased liver function blood test results) can happen during treatment with GAVRETO and may sometimes be serious. Your healthcare provider will do blood tests before and during treatment with GAVRETO to check you for liver problems. Tell your healthcare provider right away if you get any signs or symptoms of liver problem during treatment, including yellowing of your skin or the white part of your eyes (jaundice), loss of appetite, nausea or vomiting, dark “tea-colored” urine, pain on the upper right side of your stomach area, sleepiness, bleeding or bruising.
Bleeding problems: GAVRETO can cause bleeding which can be serious and cause death. Tell your healthcare provider if you have any signs or symptoms of bleeding during treatment, including vomiting blood or if your vomit looks like coffee-grounds, unusual vaginal bleeding, nose bleeds that happen often, pink or brown urine, drowsiness or difficulty being awakened, red or black (looks like tar) stools, confusion, coughing up blood or blood clots, headache, unusual bleeding or bruising of your skin, change in speech, or menstrual bleeding that is heavier than normal.
Tumor lysis syndrome (TLS): TLS is caused by a fast breakdown of cancer cells. TLS can cause you to have kidney failure and the need for dialysis treatment, an abnormal heartbeat, and may sometimes lead to hospitalization. Your healthcare provider may do blood tests to check you for TLS. You should stay well hydrated during treatment with GAVRETO. Call your healthcare provider or get emergency medical help right away if you develop any of these symptoms during treatment with GAVRETO: nausea, shortness of breath, vomiting, muscle cramps, weakness, seizures or swelling.
Risk of wound healing problems: Wounds may not heal properly during treatment with GAVRETO. Tell your healthcare provider if you plan to have any surgery before or during treatment with GAVRETO. You should not take GAVRETO for at least 5 days before surgery. Your healthcare provider should tell you when you may start taking GAVRETO again after surgery.
Before taking GAVRETO, tell your healthcare provider about all of your medical conditions, including if you:
Females who are able to become pregnant:
Males with female partners who are able to become pregnant should use effective birth control (contraception) during treatment and for 1 week after your final dose of GAVRETO.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. GAVRETO may affect the way other medicines work, and other medicines may affect how GAVRETO works.
The most common side effects of GAVRETO include: constipation, decreased levels of phosphate in the blood, high blood pressure, decreased levels of calcium in the blood, tiredness, decreased levels of body salt (sodium) in the blood, muscle and joint pain, diarrhea, abnormal liver function blood tests, and decreased white blood cell, red blood cell, and platelet counts.
GAVRETO may affect fertility in males and females, which may affect your ability to have children. Talk to your healthcare provider if this is a concern for you.
These are not all of the possible side effects of GAVRETO. Call your doctor for medical advice about side effects. You are encouraged to report side effects to the FDA. Visit FDA MedWatch or call 1-800-FDA-1088. You may also report side effects to Genentech at 1-888-835-2555.
A type of cancer treatment that targets specific types of cancer cells.
The most common type of lung cancer, named after the way cancer cells look under a microscope.
A type of cancer that forms in the thyroid and is a less common type of thyroid cancer.
Thyroid cancer that has spread to nearby tissue or distant parts of the body.
A test performed by your healthcare provider to identify the gene(s) that may impact the way a tumor grows, spreads, or reacts to certain treatments.
RET stands for rearranged during transfection, and it’s a type of gene that everyone has within their cells. In specific types of cancer cells, the RET gene is abnormal.
The molecules inside cells that carry genetic information and pass it from one generation to the next.
May be in the form of fusions or mutations; these genes drive the uncontrolled growth of cells, leading to cancer.
RET positive (RET+) stands for rearranged during transfection positive, and the term RET+ is used to describe cancer caused by abnormal RET genes.
A molecule or gene measured in tissue, blood, or other bodily fluids that can help determine the type of disease you have, how aggressive it is, and the best treatment.
Biomarker testing that is performed by your doctor that includes testing for all of the biomarkers recommended by current guidelines.
Standard chemotherapy aims to stop the growth of cancer cells by blocking all rapidly dividing cells. Chemotherapy may be given by mouth, injection, or infusion, or put directly on the skin. This depends on the type and stage of cancer being treated.
A type of cancer treatment that helps your immune system fight cancer.
A type of lung cancer driven by abnormal RET genes that has spread to other parts of the body.
A butterfly-shaped organ that makes hormones to help regulate your heart rate, metabolism, blood pressure, and body temperature.
A substance produced by glands in the body that regulates the activities of different cells and organs.
A type of targeted therapy that targets multiple types of cancer cells.
A type of thyroid cancer driven by abnormal RET genes that has spread to nearby tissue or distant parts of the body.
A type of cancer that forms in the thyroid and is the most common type of thyroid cancer.
A treatment that shrinks or kills thyroid cells. It is used to treat certain types of thyroid cancer.
When cancer spreads to other parts of the body.
A piece of DNA that gives the cells in your body instructions to perform certain functions.
When a gene breaks off and reattaches to another gene.
Any change in a cell’s DNA sequence.
When cancer has spread to other parts of the body.
May be in the form of fusions or mutations; these genes drive the uncontrolled growth of cells that leads to cancer.
All tumors have responded to a treatment and completely disappeared. This does not mean the cancer has been cured.
Tumors have responded to a treatment and shrunk in size by at least 30%.
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